Guillaume Laforge has written about how you can get Groovy with Web services RPC calls over Google Talk.
I have actually seen a bunch of applications that take use of this kind of functionality.
One smart friend has integrated Jabber with Confluence.
Imagine being able to get on IM and start asking questions, and having a bot answer them, based on your wiki.
Add voice recognition to the mix, and you can start talking to your applications :)